Computational Vascular Fluid–Structure Interaction: Methodology and Application to Cerebral Aneurysms

A computational vascular fluid–structure interaction framework for the simulation of patient-specific cerebral aneurysm configurations is presented. A new approach for the computation of the blood vessel tissue prestress is also described. Simulations of several patient-specific models are carried out, and quantities of hemodynamic interest such as wall shear stress and wall tension are studied to examine the relevance of fluid–structure interaction modeling when compared to the rigid arterial wall assumption. We demonstrate that flexible wall modeling plays an important role in accurate prediction of patient-specific hemodynamics.

Computational Fluid–Structure Interaction: Methods and Application to a Total Cavopulmonary Connection

The Fontan procedure is a surgery that is performed on single-ventricle heart patients. We focus on a patient-specific Fontan configuration, and perform a fully coupled FSI analysis of hemodynamics and vessel wall motion. A simple approach to constructing a variable-thickness blood vessel wall using Laplace operator is proposed. Rest and exercise conditions are simulated and rigid versus flexible vessel wall simulation results are compared.


  1. Long CC, Hsu M-C, Bazilevs Y, Feinstein JA, Marsden AL* (2012) Fluid–structure interaction simulations of the Fontan procedure using variable wall propertiesInternational Journal for Numerical Methods in Biomedical Engineering, 28 (2012) 512-527.
  2. Hsu M-C*, Bazilevs Y (2011) Blood vessel tissue prestress modeling for vascular fluid–structure interaction simulationFinite Elements in Analysis and Design, 47:593-599. (Most cited articles since 2009, 20102011)
  3. Bazilevs Y*, Hsu M-C, Zhang Y, Wang W, Kvamsdal T, Hentschel S, Isaksen JG (2010) Computational vascular fluid-structure interaction: Methodology and application to cerebral aneurysmsBiomechanics and Modeling in Mechanobiology, 9:481-498.
  4. Bazilevs Y*, Hsu M-C, Zhang Y, Wang W, Liang X, Kvamsdal T, Brekken R, Isaksen JG (2010) A fully-coupled fluid-structure interaction simulation of cerebral aneurysmsComputational Mechanics, 46:3-16(Web of Science Highly Cited Paper)
  5. Bazilevs Y*, Hsu M-C, Benson DJ, Sankaran S, Marsden AL (2009) Computational fluid–structure interaction: Methods and application to a total cavopulmonary connection.  Computational Mechanics, 45:77-89.
  6. Zhang Y*, Wang W, Liang X, Bazilevs Y, Hsu M-C, Kvamsdal T, Brekken R, Isaksen JG (2009) High-fidelity tetrahedral mesh generation from medical imaging data for fluid-structure interaction analysis of cerebral aneurysmsComputer Modeling in Engineering & Sciences, 42:131-150.
© Ming-Chen Hsu 2020