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Research

The Claussen group is focused on understanding/developing science and technology that interfaces with biology on the nano/microscale. The laboratory develops carbon nanomaterials (e.g., graphene, carbon nanotubes, carbon dots) and hybrid nanostructured materials for disease diagnostics/treatment, energy, molecular logic, and small-scale propulsion applications. The use of biological agents (enzymes, antibodies, DNA, cells) and surface chemistry techniques are widely explored within our research. We also seek to understand and model the reaction-diffusion kinetics associated with the nano-bio interface. These research efforts are highly interdisciplinary and require expertise from nearly all engineering and science backgrounds.

Lab on a Chip Really cool contact lens Carbon Nanoscale lab sphere

Biosensors

Wearables

Nanomaterials

Microfluidics

Nanomanufacturing

Cover Art

Nanoscale,9,48,(2017). COVER ARTICLE

Adv Healthc Mater,6,7,(2017). COVER ARTICLE

Nanoscale,35,8,(2016). COVER ARTICLE

ACS Appl. Mater. & Interfaces. 6,6, (2014). COVER ARTICLE

Nanoscale. 5,24, (2013). COVER ARTICLE

Adv. Funct. Mater. 22, 16, (2012). COVER ARTICLE

Analyst, 136, 23, (2011). COVER ARTICLE.

ACS Nano, 3, 1, (2009). COVER ARTICLE

    Journal Articles
    2018
  1. CIP2A Immunosensor Comprised of Vertically-aligned Carbon Nanotube Interdigitated Electrodes Towards Point-of-Care Oral Cancer Screening

    Shaowei Ding, Suprem R. Das, Benjamin J. Brownlee, Kshama Parate, Taylor Davis, Loreen R. Stromberg, Edward K.L. Chand, Joseph Katz, Brian D. Iverson, Jonathan C. Claussen

    Biosensors and Bioelectronics, DOI 10.1016/j.bios.2018.04.016.

  2. Printed Graphene Electrochemical Biosensors Fabricated by Inkjet Maskless Lithography for Rapid and Sensitive Detection of Organophosphates

    J. A. Hondred, J. C. Breger, N. J. Alves, S. A. Trammell, S. A. Walper, I. L. Medintz, J. C. Claussen

    Appl. Mater. & Interfaces, DOI 10.1021/acsami.7b19763.

  3. Cryoconcentration of bioflavonoid extract for enhanced biophotovoltaics and pH sensitive thin films, Appl. Mater. & Interfaces, DOI 10.1021/acsami.7b19763.

    A. Demirbas, K. Groszman, M. Pazmino, R. Nolan, D.C. Vanegas, B. Welt, J.A. Hondred, N.T. Garland, J.C. Claussen, E.S. McLamore

    Biotechnol. Prog. ,34, 1, 2018.

  4. 2017
  5. Superhydrophobic inkjet printed flexible graphene circuits via direct-pulsed laser writing

    Suprem R. Das, Srilok Srinivasan, Loreen Stromberg, Qing He, Nate Garland, Warren Straszheim, Pulickel M. Ajayan, Ganesh Balasubramanian and Jonathan C. Claussen

    Nanoscale, 9, 48, 2017(FRONT COVER ARTICLE)

  6. High resolution graphene films for electrochemical sensing via inkjet maskless lithography

    J. Hondred, L. R. Stromberg, C. L. Mosher, J. C. Claussen

    ACS Nano, DOI: acsnano.7b03554

  7. Enhanced enzymatic activity from phosphotriesterase trimer gold nanoparticle bioconjugates for pesticide detection

    John A. Hondred, Joyce Breger, Nate Garland, Eunkeu Oh, Kimihiro Susumu, Scott Walper, Igor Medintz and Jonathan C. Claussen

    Analyst, B, 142, 17, 2017

  8. Improving sensitivity of electrochemical sensors with convective transport in free-standing, carbon nanotube structures

    B. J. Brownlee, K. M. Marr, J. C. Claussen, B. D. Iverson

    Sens. Actuators, B, 20, 28, 2017

  9. Inkjet printing of single-Crystalline Bi2Te3 thermoelectric nanowire networks

    Bolin Chen, Suprem R. Das, Wei Zheng, Bowen Zhu, Biao Xu, Sungbum Hong, Chenghan Sun, Xinwei Wang, Yue Wu, Jonathan C. Claussen

    Advanced Electronic Materials, 3, 4, 2017

  10. Enabling inkjet printed graphene for ion selective electrodes with post-print thermal annealing

    Qing He, Suprem R. Das, Nathaniel T Garland, Dapeng Jing, John A. Hondred, Allison A. Cargill, Shaowei Ding, Chandran Karunakaran, and Jonathan C. Claussen

    ACS Appl. Mater. Interfaces, 9, 14, 2017

  11. Electrical differentiation of mesenchymal stem cells into schwann-cell-like phenotypes using inkjet-printed graphene circuits

    Suprem R. Das, Metin Uz, Shaowei Ding, Matthew T. Lentner, John A. Hondred, Allison A. Cargill, Donald S. Sakaguchi, Surya Mallapragada, Jonathan C. Claussen

    Advanced Healthcate Materials, 6, 7, 2017 (FRONT COVER ARTICLE)

  12. Rapid and label-free detection of interferon gamma via an electrochemical aptasensor comprising a ternary surface monolayer on a gold interdigitated electrode array

    Shaowei Ding, Curtis Mosher, Xian Y. Lee, Suprem R. Das, Allison A. Cargill, Xiaohui Tang, Bolin Chen, Eric S. McLamore, Carmen Gomes, Jesse M. Hostetter, and Jonathan C. Claussen

    ACS Sensors, 2, 2, 2017

  13. 2016
  14. PulSED: pulsed sonoelectrodeposition of fractal nanoplatinum for enhancing amperometric biosensor performance

    M Taguchi, N Schwalb, Y Rong, DC Vanegas, N Garland, M Tan, H Yamaguchi, JC Claussen, ES McLamore

    Analyst, 141,11,2016

  15. A volume miniaturized hydrogen peroxide sensor based on peroxidase activity of copper(ii) chlorophyllin on zinc oxide and polypyrrole nanocomposite

    Balamurugan, Murugesan; Santharaman, Paulraj; Madasamy, Thangamuthu; Claussen, Jonathan; Karunakaran, Chandran

    Sensor Letters, 14,7,2016

  16. Label-free electrochemical immunosensor for the rapid and sensitive detection of the oxidative stress marker Superoxide Dismutase 1 at the point-of-care

    Paulraj Santharaman, Mainak Das, Sushil K Singh, Niroj K Sethy, Kalpana Bhargava, Jonathan C Claussen, Chandran Karunakaran

    Sensors and Actuators B: Chemical, 236,29,2016

  17. Platinum nanoparticle decorated SiO2 microfibers as catalysts for micro unmanned underwater vehicle propulsion

    Bolin Chen, Nathaniel T. Garland, Jason Geder, Marius Pruessner, Eric Mootz, Allison Cargill, Anne Leners, Granit Vokshi, Jacob Davis, Wyatt Burns, Michael A. Daniele, Josh Kogot, Igor L. Medintz, and Jonathan C. Claussen

    ACS Appl. Mater. Interfaces, 8,45,2016

  18. 3D nanostructured inkjet printed graphene via UV-pulsed laser irradiation enables paper-based electronics and electrochemical devices

    Suprem R. Das, Qiong Nian, Allison A. Cargill, John A. Hondred, Shaowei Ding, Mojib Saei, Gary J. Cheng and Jonathan C. Claussen

    Nanoscale, 8, 35, 2016 (FRONT COVER ARTICLE)

  19. A paper based graphene-nanocauliflower hybrid composite for point of care biosensing

    Stephanie L. Burrs, M. Bhargava, R. Sidhu, J. Kiernan-Lewis, Carmen Gomes, Jonathan C. Claussen and Eric McLamore

    Biosens. Bioelectron., 85, 15, 2016

  20. 2015
  21. Biosensing with förster resonance energy transfer coupling between fluorophores and nanocarbon allotropes

    Shaowei Ding, Allison A. Cargill, Suprem R. Das, Igor L. Medintz and Jonathan C. Claussen

    Sensors, 15, 6, 2015

  22. High aspect ratio carbon nanotube membranes decorated with pt nanoparticle urchins for micro underwater vehicle propulsion via H2O2 decomposition

    Kevin M. Marr, Bolin Chen, Eric J. Mootz, Jason Geder, Marius Pruessner, Brian J. Melde§, Richard R. Vanfleet∥, Igor. L. Medintz, Brian D. Iverson, and Jonathan C. Claussen

    ACS Nano, 9, 8, 2015

  23. Increasing the activity of immobilized enzymes with nanoparticle conjugation

    Shaowei Ding, Allison A. Cargill, Igor L. Medintz, Jonathan C. Claussen

    Curr. Opin. Biotechnol., 34, 2015

  24. Probing the Enzymatic Activity of Alkaline Phosphatase within Quantum Dot Bioconjugates

    J.C. Claussen, A. Malanoski, J.C. Breger, E. Oh, S.A. Walper, K. Susumu, R. Goswami, J.R. Deschamps, I.L. Medintz

    J. Phys. Chem. C., 9, 8, 2015

  25. 2014
  26. Three-dye dynamic DNA scaffolds for photonic switching and logic through fluorescence resonance energy transfer

    S. Buckout-White, J.C. Claussen, M.G. Ancona, E. White, I.L. Medintz

    RSC Advances, 4, 90,2014

  27. Platinum-paper micromotors: An urchin-like nanohybrid catalyst for green monopropellant bubble-thrusters

    J.C. Claussen, M. A. Daniele, J. Gedder, M. Pruessner, Antti J. Mäkinen, B. Melde, Mark Twigg, Jasenka Verbarg, and Igor Medintza

    ACS Appl. Mater & Interfaces, 6, 20,2014(FRONT COVER ARTICLE)

  28. Nanomaterial-mediated biosensors for monitoring glucose

    M. Taguchi, A. Ptitsyn, E.S. McLamore, J.C. Claussen

    Journal of diabetes science and technology, 8,2,2014

  29. 2013
  30. Complex logic functions implemented with quantum-dot bionanophotonic circuits

    J.C. Claussen, N. Hildebrandt, K. Susumu, M.G. Ancona, I.L. Medintz

    ACS Applied Materials & Interfaces, 6,6,2013

  31. Biophotonic logic devices based on quantum dots and temporally-staggered Förster energy transfer relays

    J.C. Claussen, W.R. Algar, N. Hildebrandt, K. Susumu, M.G. Ancona, I.L. Medintz

    Nanoscale, 5,24,2013(FRONT COVER ARTICLE)

  32. Emerging technologies for non-invasive quantification of physiological oxygen transport in plants

    P. Chaturvedi, M. Taguchi, S.L. Burrs, B.A. Hauser, W. Salim, J.C. Claussen, E. S. McLamore

    Planta, 238,3,2013

  33. 2012
  34. Acoustic droplet vaporization and propulsion of perfluorocarbon‐filled microbullets for targeted tissue penetration and deformation

    J.C. Claussen, D. Kagan, M.J. Benchimol, E. Chuluun‐Erdene, S. Esener, J. Wang

    Angewandte Chemie, 124,30,2012

  35. Nanostructuring platinum nanoparticles on graphene petal nanosheets for electrochemical biosensing

    J.C. Claussen, A. Kumar, D.B. Jaroch, M.H. Khawaja, A.B. Hibbard, D.M. Porterfield, T.S. Fisher

    Advanced Functional Materials, 22,16,2012(FRONT COVER ARTICLE)

  36. Multiplexed and switchable release of distinct fluids from microneedle platforms via conducting polymer nanoactuators for potential drug delivery

    J.C. Claussen, G. Valdés-Ramírez, J.R. Windmiller, A.G. Martinez, F. Kuralay, M. Zhou, R. Narayan, J. Wang

    Sensors and Actuators B: Chemical, 161,1,2012

  37. 2011
  38. Bacterial isolation by lectin-modified microengines

    S. Campuzano, J. Orozco, D. Kagan, M. Guix, W. Gao, S. Sattayasamitsathit, J.C. Claussen, A. Merkoci, J. Wang

    Nano Letters, 12,1,2011

  39. Effects of Carbon Nanotube-Tethered Nanosphere Density on Amperometric Biosensing: Simulation and Experiment

    J.C. Claussen, J.B. Hengenius, M.M. Wickner, T.S. Fisher, D.M. Umulis, D.M. Porterfield

    The Journal of Physical Chemistry C., 115,43,2011

  40. A comparative study of enzyme immobilization strategies for multi-walled carbon nanotube glucose biosensors

    J. Shi, J.C. Claussen, E.S. McLamore, A. ul Haque, D. Jaroch, A.R. Diggs, P. Calvo-Marzal, J. L. Rickus, D.M. Porterfield

    Nanotechnology, 22,35,2011

  41. Electrochemical glutamate biosensing with nanocube and nanosphere augmented single-walled carbon nanotube networks: a comparative study

    J.C. Claussen, M.S. Artiles, E.S. McLamore, S. Mohanty, J. Shi, J.L. Rickus, T.S. Fisher, D.M. Porterfield

    Journal of Materials Chemistry, 21,30,2011

  42. Microbiosensors based on DNA modified single-walled carbon nanotube and Pt black nanocomposites

    J. Shi, T.G. Cha, J.C. Claussen, A.R. Diggs, J.H. Choi, D.M. Porterfield

    Analyst 136, 136,23,2011(FRONT COVER ARTICLE)

  43. Transforming the fabrication and biofunctionalization of gold nanoelectrode arrays into versatile electrochemical glucose biosensors

    J.C. Claussen, M. Wickner, T.S. Fisher, D.M. Porterfield

    ACS Applied Materials & Interfaces, 3,5,2011

  44. A self-referencing platinum nanoparticle decorated enzyme-based microbiosensor for real-time measurement of physiological glucose transport

    E.S. McLamore, J. Shi, D. Jaroch, J.C. Claussen, A. Uchida, Y. Jiang, W. Zhang, M.K. Banks, K.K. Buhman, D. Teegarden, J.L. Rickus, D.M. Porterfield

    Biosensors and Bioelectronics, 26,5,2011

  45. 2010
  46. Oscillatory glucose flux in INS1 pancreatic Beta cells: a self-referencing microbiosensor study

    J. Shi, E.S. McLamore, D. Jaroch, J.C. Claussen, J.L. Rickus, D.M. Porterfield

    Analytical Biochemistry, 411,2,2010

  47. Electrochemical glucose biosensor of platinum nanospheres connected by carbon nanotubes

    J.C. Claussen, S.S. Kim, A. ul Haque, M.S. Artiles, D.M. Porterfield, T.S. Fisher

    Journal of Diabetes Science and Technology, 4,2,2010

  48. A self-referencing glutamate biosensor for measuring real-time neuronal glutamate flux

    E.S. McLamore, S. Mohanty, J. Shi, J. Claussen, J.L. Rickus, S. Jedlicka, D.M. Porterfield

    Journal of Neuroscience Methods, 189,1,2010

  49. 2009
  50. Electrochemical biosensor of nanocube-augmented carbon nanotube networks

    J.C. Claussen, A.D. Franklin, A. ul Haque, D.M. Porterfield, T.S. Fisher

    ACS Nano, 3,1,2009(FRONT COVER ARTICLE)

  51. 2008
  52. Independently addressable fields of porous anodic alumina embedded in SiO2 on Si

    A.D. Franklin, D.B. Janes, J.C. Claussen, T.S. Fisher, T.D. Sands

    Applied Physics Letters, 92,1,2008

  53. Book Chapters
  54. "Microbial Pathogen Detection Strategies"

    D. Vanegas, J.C. Claussen, E.S., McLamore, C. Gomes

    Encyclopedia of Agricultural, Food, and Biological EngineeringThird Edition, Taylor & Francis, (2017), ISBN 9781439811115

  55. "Synthesis and applications of cellulose nanohybrid materials"

    Nathaniel T. Garland, Eric S. McLamore, Carmen Gomes, Ethan A. Marrow, Michael A. Daniele, Scott Walper, Igor L. Medintz, Jonathan C. Claussen

    Hybrid Polymer Composite MaterialsElsevier, (2017), ISBN 978-0-08-100785-3

  56. "Biomimetic Fractal Nanometals As A Transducer Layer in Electrochemical Biosensing"

    ES McLamore, M Convertino, I Ocsoy, DC Vanegas, M Taguchi, Y Rong, C Gomes, P Chaturvedi, JC Claussen

    Semiconductor-Based Sensors World Scientific, (2016), ISBN 978-981-3146-72-3

  57. "Hybrid metallic nanoparticles: enhanced bioanalysis and biosensing via carbon nanotubes, graphene, and organic conjugation"

    M. Daniele, S. Campuzano, F. Kirilay, E.S. McLamore, Allison Cargill, Shaowei Ding, J.C. Claussen

    Nanobiosensors and Nanobioanalyses. Springer, (2015), ISBN 978-4-431-55189-8

  58. "FRET-based cellular sensing with genetically encoded fluorescent indicators"

    J.C. Claussen, I.L. Medintz FRET – Förster Resonance Energy Transfer. From Theory to Applications. Wiley-VCH, (2013), ISBN: 9783527656028

  59. "Nano-sized biosensors"

    J.C. Claussen, J. Shi, C.S. Rout, M.S. Artiles, M.M. Wickner, M.S. Stensberg, D.M. Porterfield, T.S. Fisher

    Biosensors for Medical Applications, Woodhead Publishing, (2012), ISBN 1 84569 935

  60. Electrochemical Biosensors of Carbon Nanotubes

    J.C. Claussen, J. Shi, A.R. Diggs, D.M. Porterfield, T.S. Fisher

    Nanomaterials for the Life Sciences, Wiley-VCH, (2011), ISBN 978-3-527-32169-8

  61. Conference Proceedings
  62. "Impedance biosensor for the rapid detection of Listeria spp. based on aptamer functionalized Pt-interdigitated microelectrodes array"

    R. Sidhu ; Y. Rong ; D. C. Vanegas ; J. Claussen ; E. S. McLamore ; C. Gomes

    Smart Biomedical and Physiological Sensor Technology XIII, Maryland, United States (2016).

  63. "Bio-inspired patterned networks (BIPS) for development of wearable/disposable biosensors"

    E. S. McLamore ; M. Convertino ; John Hondred ; Suprem Das ; J. C. Claussen ; D. C. Vanegas ; C. Gomes

    Smart Biomedical and Physiological Sensor Technology XIII, Maryland, United States (2016).

  64. "Effect of platinum nanoparticle deposition parameters on hydrogen peroxide transduction for applications in wearable electrochemical glucose biosensors"

    Allison A. Cargill ; Kathrine M. Neil ; John A. Hondred ; Eric S. McLamore ; Jonathan C. Claussen

    Smart Biomedical and Physiological Sensor Technology XIII, Maryland, United States (2016).

  65. "Enhancing molecular logic through modulation of temporal and spatial constraints with quantum dot-based systems that use fluorescent (förster) resonance energy transfer"

    J.C. Claussen, W. R. Algar, N. Hildebrandt, K. Susumu, M. G. Ancona, I.L. Medintz

    SPIE Nanoscience & Engineering Meeting, San Diego, CA. (2013).

  66. “Biosensor capture kinetics model of nanocube-augmented carbon nanotube networks,”

    J.C. Claussen, A. ul Haque, T.S. Fisher, M.D. Porterfield

    Materials Research Society Conference, Boston, MA. (2009).

  67. Research Reports
  68. "Nanoparticle biosensor for noninvasive glucose sensing."

    Sensing & Measurements, SPIE Newsroom – Nanotechnology (2013), DOI: 10.1117/2.1201308.005030

  69. “Using Nanotechnology to Improve Lab on a Chip Devices”

    J.C. Claussen, I.L. Medintz

    J. Biochip Tissue Chip., (2012), DOI: 10.4172/2153-0777.1000e117

Our Amazing Team

Researchers and Students

Dr. JC

Dr. Jonathan Claussen

Phone: 515-294-4690

Address: 2624F, Howe Hall, Virtual Reality Applications Center (VRAC) | Iowa State University | Ames, IA 50011

Email: jcclauss@iastate.edu



Loreen Stromberg

Postdoc

Bolin Chen

PhD student

Shaowei Ding

PhD candidate

Nate Garland

PhD student

Lucas Hall

PhD student

John Hondred

PhD student

Kshama Parate

PhD student

Matthew Kruse

MS student

Fred Mace

Undergradute, ME

Jonathan Green

Undergradute, ME

Abraham Polonia-Suarez

Undergradute, ME

Please contact Prof. Claussen via email if you are interested in joining the group. We are currently looking for highly motivated postdocs, graduate students, and undergraduate students to join the group.

Alumni

Postdocs

Enjoying the Moments

The group has some fun!

MRS Conference 2017

Final oral defense

giggles

MRS conference 2015

Skiing

Fun with Cy

giggles

Laser tag

Eating Pizza

Facilities

Where the Magic Happens

Black Engineering

Student and Graduate Student Office Space located at VRAC.

Gilman Hall

Laboratory space with chemical/biological hoods located at Gilman Hall.

Applied Sciences

Cleanroom and nano-manufacturing/characterization located at the Applied Sciences Complex.

Aerial ISU

Drop on by some time!